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To call Javascript function on onchange event of Dropdownlist before server side event handler for SelectedIdexChanged event is called.

This is some what tricky as mentioning onchange = "return function(this);" in .aspx page will not work properly.

In this case we need to add 'if' codition as below

in .aspx page for dropdown list mention onchange as

onchange = "if (!confirmSubmit()){return};"

or else you can add attributes for dropdownlist as below

Dropdownlist1.Attributes.Add(
"onchange", "if (!confirmSubmit()){return};");